Research | İstinye University


1. Kacar O, Cevatemre B, Hatipoglu I, Arda N, Ulukaya E, Yilmaz VT, Acilan C. The role of cell cycle progression for the apoptosis of cancer cells induced by palladium(II)-saccharinate complexes of terpyridine. Bioorg Med Chem 25:1770-1777, 2017.

2. Ari F, Aztopal N, Erkisa M, Celikler S, Sahin S, Ulukaya E. Nonapoptotic cell death induced by Hypericum species on cancer cells. Eur Res J 3(1):1-10. 2017

3. Tunc D, Dere E, Karakas D, Cevatemre B, Yilmaz VT, Ulukaya E. Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines. Bioorg Med Chem 25:1717-1723, 2017

4. Aydinlik S, Erkisa M, Cevatemre B, Sarimahmut M, Dere E, Ari F, Ulukaya E. Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line. Biochim Biophys Acta 1861:49-57, 2017

5. Aztopal N, Karakas D, Cevatemre B, Ari F, Icsel C, Daidone MG, Ulukaya E. A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer. Bioorg Med Chem. 25:269-276, 2017

6. Ikitimur-Armutak EI, Gurel-Gurevin E, Kiyan HT, Aydinlik S, Yilmaz VT, Dimas K, Ulukaya E. Anti-angiogenic effect of a Palladium(II)-Saccharinate Complex of Terpyridine in vitro and in vivo. Microvasc Res.109:26-33, 2017

7. Acilan C, Cevatemre B, Adiguzel Z, Karakas D, Ulukaya E, Ribeiro N, Correia I, Pessoa JC. Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents. Biochim Biophys Acta. 1861:218-234, 2017

8. Oral AY, Oral HB, Sarimahmut M, Cevatemre B, Ozkaya G, Korkmaz S, Ulukaya E. Combination of esomeprazole with chemotherapeutics results in more pronounced cytotoxic effect via apoptosis on A549 nonsmall-cell lung cancer cell line. Turk J Biochem 41: 231-241, 2017.

9. Coskun D, Erkisa M, Ulukaya E, Coskun MF, Ari F. Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity. Eur J Med Chem 136: 212-222, 2017

10. Stasevych M, Zvarych V, Lunin V, Deniz NG, Gokmen Z, Akgun O, Ulukaya E, Poroikov V, Gloriozova T and Novikova V. Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents. SAR and QSAR in Environmental Research; 28(5):355-366. 2017

11. Acilan C……. Ulukaya E…. A palladium(II)-saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model. Anticancer Drugs, 28(8):898-910, 2017.

12. Arı F, Çelikler S, Karakas D, Cevatemre B, Fırat M, Ulukaya E. Total Phenolic Content, Antioxidant and Cyto-/Genotoxic Activities of Pelargonium quercetorum Agnew in Human Breast Cancer Cells, Journal of Clinical and Experimental Investigations, Volume 8, Issue 1, Pages 22 – 30, 2017.

13. Yilmaz VT, Icsel C, Suyunova F, Aygun M, Cevatemre B and Ulukaya E. Synthesis, structures, DNA/protein binding, molecular docking, anticancer activity and ROS generation of Ni(II), Cu(II) and Zn(II) 5,5-diethylbarbiturate complexes with bis(2-pyridylmethyl)amine and terpyridine (Accepted by New Journal of Chemistry)

14. Duman FD, Erkisa M, Khodadust, Ari F Ulukaya E, Acar HY. Folic Acid-Conjugated Cationic Ag2S Quantum Dots For Optical Imaging and Selective Doxorubicin Delivery to HeLa Cells. Nanomedicine; 12(19):2319-2333, 2017.

15. Karakas D. Ari F. Ulukay E. The MTT viability assay yields strikingly false-positive viabilities although the cells are killed by some plant extracts, Academic J. 

16. Cevatemre B,… Ulukaya E. A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer. (Accepted by pharmacological research). 129:500-514, 2018

17. Aztopal N, Erkisa M, Erturk E, Tokullugil A, Ulukaya E, Ari F. Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells. Chemico-Biological Interactions; 25;280:51-58; 2018.

18. Aybastier O, Dawbaa S, Demir C, Akgün O, Ulukaya E, Ari F. Quantification of DNA damage products by gas chromatography tandem mass spectrometry in lung cell lines and prevention effect of thyme antioxidants on oxidative induced DNA damage. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 808:1-9, 2018.

19. Sereti E, Karagianellou T, Kotsoni I, Magouliotis D, Kamposioras K, Ulukaya E, Sakellaridis N, Zacharoulis D, Dimas K. Patient Derived Xenografts (PDX) for personalized treatment of pancreatic cancer: emerging precious allies in the war on a devastating cancer. Journal of Proteomics. 30;188:107-118, 2018.

20. Buyukeksi SI, Erkisa M, Sengul A, Ulukaya E, Oral AY. Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)–2,2′:6′,2″‐ terpyridine with rigid dianionic 1,2,4‐triazole‐3‐sulfonate Linker. Applied Organometallic Chemistry. Volume32, Issue8; 2018.

21. Gurevin EG, Kiyan HT, Esener OBB, Aydinlik S, Uvez A, Ulukaya E, Dimas K, Armutak EI. Chloroquine Used in Combination with Chemotherapy Synergistically Suppresses Growth and Angiogenesis In Vitro and In Vivo. Anticancer Res.; 38(7):4011-4020, 2018

22. Yilmaz VT, Icsel C, Turgut OR, Aygun M, Erkisa M, Turkdemir MH, Ulukaya E. Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA. Eur J Med Chem:155: 609-622, 2018.

23. Icsel C, Yilmaz VT, Aygün M, Cevatemre B, Alper P, Ulukaya E. Palladium(II) and platinum(II) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells. Dalton Transactions, 21;47(33):11397-11410, 2018.

24. Turhan Buz P, Demir Duman F, Erkisa M, Demirci G, Ari F, Ulukaya E & Yagci Acar H. Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect. Nanomedicine, 14(8):969-987; 2019.

25. Aydinlik S, Dere E, & Ulukaya E. Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells. Biochimica et Biophysica Acta (BBA)-General Subjects, 1863(5):903-916, 2019.

26. Icsel C, Yilmaz VT, Cevatemre B, Aygun M, & Ulukaya E. Structures and anticancer activity of chlorido platinum (II) saccharinate complexes with mono-and dialkylphenylphosphines. Journal of Inorganic Biochemistry, 14;195:39-50, 2019.

27. Çebi A, Akgün E, Çelikler S, Firat M, Özel MZ, Ulukaya E, & Ari F. Cytotoxic and genotoxic effects of an endemic plant of Turkey Salvia kronenburgii on breast cancer cell lines, 2019.

28. Ayaz F, Küçükboyacı N, Gören N, Çalış İ, Aydınlık Ş, Ulukaya E, ... & Choudhary, M. I. Bioassay-guided isolation of cytotoxic compounds from Chrysophthalmum montanum (DC.) Boiss. Food and Chemical Toxicology, 125, 10-20, 2019.  

29. Erkisa M, Karakas D, & Ulukaya E. Cancer Stem Cells: Root of the Evil. Critical Reviews™ in Oncogenesis, 24(1), 2019.

30. Ozturk S, Erkisa M, Oran S, Ulukaya E, Celikler S, & Ari F. Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis. Drug and chemical toxicology, 1-9, 2019.

31. Karakas D, Cevatemre B, Oral AY, Yilmaz VT, Ulukaya E. Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation. Anticancer Agents Med Chem, 2019.